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Chemistry - Materials
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Energy, Ecology, Environment
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Quality of life - Health - Food
ICSN - Department of Chemical Biology
Research team
The Department of Chemical Biology (or chemobiology) is interested in the understanding of biological processes at the molecular and cellular level, but also their modulation and detection in living organisms. Processes of the plant, animal or bacterial world are studied such as the growth of plants, the metabolism of bacteria or pathogenic cells, oxidative stress in mammalian cells. This is made possible by the collaboration of chemists, biochemists and biologists grouped under two themes: probes and modulators for biological targets (https://icsn.cnrs.fr/recherche/cb/sondes-et-modulateurs-pour-cibles-biologiques/activites-de-recherche) and redox signaling / function of Fe-S proteins (https://icsn.cnrs.fr/recherche/cb/signalisation-redox-et-fonctions-des-proteines-fe-s), and of a platform for screening bioactive compounds, CIBI (https://icsn.cnrs.fr/plateformes/cibi).
Innovation themes
Lab of attachment
1, avenue de la Terrasse
91198 GIF-SUR-YVETTE
Expertises
Organic and inorganic chemistry:
- design and synthesis of molecular probes and inhibitors
- click chemistry
- glycochemistry
- boron and lanthanide chemistry
- total synthesis
Molecular and cellular biology:
- evaluation of the viability and cell proliferation of angiogenesis and tumor vascularization
- studies of mechanisms of cell death, cell cycle regulation and chemoresistance phenomena
- homeostasis of iron and redox species
Phenotypic and High Throughput Screening (HTS) on isolated targets
Biochemistry and enzymology:
- production, purification and analysis of recombinant proteins
- protein-ligand and protein-protein interaction (amidotransferase, Fe-S protein, strigolactone receptors, etc.)
- test design, mechanistic study, catalysis and inhibition
Metabolic labeling:
- Gram negative and positive bacteria
- mammalian cells
Applications sectors
- Health / wellness
- Chemistry / Plastics (Glue, Plastic, Rubber...)
Total number of employees
Number of researchers : 9
Number of doctoral students : 5
Equipment(s) open to collaboration
- synthesis microwaves, flow chemistry, preparative HPLC
- cell culture rooms, microbiology room L1
- pipetting-diluter robots (Biomek Fx, Nx and Biomek 3000), flow cytometer, microplate readers
- epifluorescence microscope
- spectrophotometers of circular dichroism, UV-Visible absorption and fluorescence
- FPLC (AKTA)
- glove box
Keywords
- oxidative stress
- nitrosating stress
- protein
- Fe-S
- nitric oxide
- NO
- hydrogen peroxide
- H2O2
- redox signaling
- mammalian cell
- cell biology
- molecular biology
- biochemistry
- enzyme
- enzymology
- mutagenesis
- kinetics
- inhibition
- biophysics
- UV-visible absorption
- fluorescence
- luminescence
- NtN-hydrolase
- amidotransferase
- galactosidase
- receptor
- protein-ligand interaction
- strigolactones
- lipochitooligosaccharides
- N-acetylglucosamine
- glycochemistry
- metabolic labeling
- click chemistry
- probes
- molecular imaging
- agent contrast
- lanthanide
- gadolinium
- MRI
- optical imaging
- polyamine
- therapeutic chemistry
- total synthesis
- boron
- flow chemistry
- microwaves
- antibiotics
- structure-activity
- synthetic tools
- plant growth
- plants
- screening
- angiogenesis
- phenotypic
- oncology
- cancer
- apoptosis
Valuation offer
Projects examples
- determination of the mechanism of reception of strigolactones in vascular plants
- total synthesis of tiacumicyne B
- development of detection methods for pathogenic bacteria
- multimodal probe design for enzymatic activity imaging
- glycosylations with iron (III) salts
Industrial and scientific relations
Scientific collaborations
- France: the chemical biology department has several academic collaborations at the national level with chemistry and biology laboratories of different universities and organizations (CNRS, CEA, INSERM, INRA, Institut Pasteur, I2BC), LABEX (CHARMMMAT) and the hospital environment .
- Europe: University of Ghent (Belgium), Institute of Genetics and Livestock (Poland)
Private collaborations
Many industrial contracts (provision of equipment, collaboration, service provision) are regularly implemented with large companies, SMEs or startups in the pharmaceutical, biotechnology, food and scientific instrumentation sectors.