I2BC / Plateforme de mesures d'Interactions Macromoléculaires (PIM)

The I2BC's Macromolecular Interactions Measurement Platform (MIP) offers a wide range of equipment and expertise in biochemistry and biophysics for quality control measurements and functional analysis of protein samples: microcalorimetry (ITC: Isothermal Titration Calorimetry and DSC: Differential Scanning Calorimetry), analytical ultracentrifugation (UCA), MST (Microscale Thermophoresis), SEC-RALS-LALS, BLI (Biolayer Interferometry), switchSENSE and more recently FIDA (Flow Induced Dispersion Analysis).
The services offered by the platform include: 1) Biophysical characterisation of proteins or biological complexes (SEC-RALS-LALS, UCA and FIDA) - 2) Analysis of biological interactions (ITC, BLI, switchSENSE, MST and FIDA) - 3) Analysis of the stability of macromolecules and biological complexes, in particular as an aid to formulation (DSC, DSF and TSA).
The equipment and services are available to all Université Paris-Saclay laboratories, other academic laboratories and industry.
For more information about these services: plateforme-pim@i2bc.paris-saclay.fr.
This platform is part of the I2BC Structural Biology Platforms cluster, which includes: i) the Crystallisation, NMR, CryoEM, Macromolecular Interaction Measurements and alphaRep platforms, and ii) the technical platforms for Soluble or Membrane Protein Expression in Yeast and Protein Expression in Insect Cells.

• Mrs Magali AUMONT-NICAISE
• Mrs Stéphanie MARSIN
• Mrs Magali NOIRAY
• Mr Stéphane PLANCQUEEL