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Pulmonary hypertension: pathophysiology and novel therapies (HTAP)

Research unit


Inserm UMR-S 999 is a major actor in national and international translational research on pulmonary hypertension, leading to major physiopathological, medical and surgical advances. It is subdivided into two research, physiopathological and clinical teams composed of researchers, clinicians and surgeons who have been working in synergy since 2010. Thanks to a national register of patients (National Reference Center for Severe Pulmonary Hypertension), a biobank of cells and tissues, and an internationally recognized expertise, the two teams are studying the mechanisms of pulmonary vascular remodeling and associated heart disease in humans, rodents and large animals.


  • Mr Marc HUMBERT

Innovation themes

Map and access

133, avenue de la Résistance

Our research areas


- pulmonary hypertension
- cardiovascular physiopathology
- pulmonary vascular remodeling
- inflammation, autoimmunity
- endothelial dysfunction
- epigenetics
- ionic channels
- right ventricular remodeling
- experimental models of pulmonary hypertension
- management of pulmonary hypertension
- therapeutic Innovation
- surgical innovation
- biomarkers

Applications sectors

  • IT / software
  • Biotechnology
  • Health / wellness
  • Education / Training

Total number of employees

Total number of employees : 71
Number of researchers : 35
Number of doctoral students : 10

Equipment(s) open to collaboration

Academics and industry:
- MacsQuant Flow Cytometry System (Miltenyi)
- EnVision 2103 Plate Reader (Perkin Elmer)
- FlexStation 3 multimode reader (molecular devices)
- StepOne + Real-Time PCR-Q System (Applied Biosystems)
- thermocyleur T100 PCR (Bio-Rad)
- ChemiDoc system (Bio-Rad) for multiple detection: fluorescence, colorimetry, densitometry, chemiluminescence
- Nanodrop
- routine microscopes (Leica and Nikon)
- hypoxic chambers for rodents
- confocal microscope LSM 00 (Zeiss)
- PALM MicroBeam laser microdissector (Zeiss)
- cryomicrotome (Leica)
- UV Stratalinker 2400 (Stratagene)
- electrophysiology / calcium imaging station
- auger (Zeitz) and polisher
- microtome with vibrating blade (Microm)
- system of isolation of cardiomyocytes by retrograde perfusion of type Langendorff
- ultrasound (GE Healthcare)
- small animal catheterization station (mice, rats)
- large animal experimental surgery block (pig)


Our results

Valuation offer

Know-how :
- management of pulmonary hypertensions - measurement of hemodynamic parameters in humans and animals (right ventricular catheterization or pulmonary artery, ultrasound...)
- experimental models of pulmonary hypertensions and right cardiac hypertrophy (rat, pig, mouse) - pulmonary vascular cell isolation and cardiac dissociationElectrophysiology (cardiac and vascular cells)

Database: Register of the French PAH network https://registre-htap.aphp.fr

Biological material: Bio-bank of tissues and cells of PAH patients http://www.u999.u-psud.fr/fr/presentation-de-l-unite/recherche-translationnelle/htaptheque.html

Patents: 9 patents filed

Projects examples

- Hôpital Marie Lannelongue (France): project PIA2 RHU Bio-Art Lung 2020, development of an artificial lung
- Technion (Israel): screening for PAH in breath with an electronic nose

Industrial and scientific relations

Scientific collaborations

- Europe: Netherlands, Belgium, England, Germany, Italy, Portugal, Spain, Switzerland
- International: Canada, United States, Israel, Brazil, China, Japan

Private collaborations

- France: ImmunID Technologies, MIFCARE
- Europe: Bayer Allemagne, Inovultus
- Internationnal: Bristol Myers-Squibb, Bayer, GSK, Bayer Healthcare, Sanofi, Actelion Pharmaceuticals, GlaxoSmithKline, Pfizer, Gilead (not exhaustive)


Establishments of affiliation