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Physiopathologie et Pharmacologie Clinique de la Douleur (LPPD)

Research unit


The LPPCD focuses on the mechanisms of hyperalgesia and allodynia in humans, that is, on neurological phenomena involving exacerbated pathological pain. This research theme represents a major public health focus up to 30% of the total population. Located on the CHU Ambroise Paré site in Boulogne Billancourt, the unit has a clinical research vocation and works closely with a large number of patients with acute or chronic pathological pain. In addition, the unit's clinician network, coming from different Paris hospitals, offers a real wealth of samples and patients to coordinate major clinical trials in the field.


  • Mr Didier BOUHASSIRA

Innovation themes

Map and access

9, avenue Charles de Gaulle
Hôpital Ambroise Paré Centre d'évaluation et de traitement de la douleur

Our research areas


- physiology and pathophysiology of pain
- management of acute and chronic pain
- therapeutic innovation
- clinical tests
- post-operative, musculoskeletal, visceral, cancer pain
- interaction microbiote
- nociception
- correlations between cognition and pain
- nociceptive tests in humans (cold pressure, heat threshold, electrical stimulation, mechanical pressure ...)
- experimental models of acute and chronic pain

Applications sectors

  • IT / software
  • Biotechnology
  • Health / wellness
  • Education / Training

Total number of employees

Total number of employees : 17
Number of researchers : 8
Number of doctoral students : 4


Our results

Projects examples

- development of a repeated cortical stimulation method as an analgesic procedure for the long term


Establishments of affiliation