• Energy, Ecology, Environment
  • Quality of life - Health - Food

MICrobiologie de l'ALImentation au Service de la Santé Humaine

Research unit

Description

MICALIS develops innovative research in the field of Microbiology of Food for Health. The researchers at this unique institute in France are working on the study of food and intestinal microbial ecosystems and interactions with the host, emergence and control of opportunistic foodborne pathogenic microorganisms as well as microbial systemic and synthetic biology. The institute is home to 5 technological platforms: - Axenic animal facility - Microscopy and imaging of microorganisms, Southwestern Paris proteomic analysis - Microbial-yeast resources - Preindustrial demonstration of intestinal metagenomics. The work and patents on the improvement of the production of edible leaven, the prevention of the microbiological risk in the food chain and the production of tools for the diagnosis of human pathologies and nutritional and probiotic strategies, allows the institue to be an active socio-economic partner (Probiox, Danone).

Contacts

  • Mr Philippe NOIROT

http://www.micalis.fr/

Innovation themes

Map and access

Domaine de Vilvert
78350 JOUY-EN-JOSAS

Our research areas

Expertises

- microbiota
- meat ecosystem
- encephalic and metabolic pathologies
- bioadhesion and materials hygiene
- bacterial communication
- microbial genetics and environment
- firmicutes and environment
- microbial adaptation
- bacterial wall
- bacterial genetics
- biofilm in bacillaceae virulence and fungal infection
- epigenetics
- cellular microbiology
- microbial lipid metabolism
- bacterial communication
- functional integration of cellular processes
- bioinformatics
- bacteriophage genomes

Applications sectors

  • Agriculture
  • Health / wellness
  • Agri-food industry

Total number of employees

Total number of employees : 340
Number of researchers : 130
Number of doctoral students : 140

Equipment(s) open to collaboration

Academics and industry:
Mass Spectrometers:
- Qexactive
- LTQ-Orbitrap
- LTQ-XL

Microscopy: transmission electron microscopy, scanning microscope, confocal laser scanning, structured illumination microscopy (Apotome), videomicroscopy, Medical Imaging for Animal Development and Reproduction, Cellvizio-Lab endomicroscopy, bioluminescence imaging on small animals, Virtual blades scanner

Keywords

Our results

Projects examples

- identification and use of a new beneficial commensal bacterium, Faecalibacterium prausnitzii, on the basis of human clinical data: Publication in PNAS at the end of 2008 (450 citations in ISI Wb of Knowledge), Obtaining a project from the Unique Interministerial Fund In the amount of ? 4 million, a first patent filed on peptides and development of the first gnotobiotic model with F. prausnitzii (recently published in BMC Biol.)
- screening of a panel of 150 strains of lactic acid bacteria that led to the identification of a new probiotic strain of Lactobacillus plantarum that has been shown to be effective against the influenza virus. This work was published in AEM and a patent. Our industrial partner conducted a clinical trial of this strain, the results of which will be known in September 2013
- identification of new mechanisms involved in the microbiota / host dialogue. Supported by 3 industrial projects Syndifrais and by funding INRA young team. Using gnotobiotic animals, microbiota and food-borne bacteria have been shown to influence the structure and functions of absorption and protection of the intestine (Faseb J 2013, Isme J, 2014).
- we have developed new concepts of therapeutic innovations based on the use of recombinant bacteria (Gene Therapy, 2008, Science Translational Medicine, 2012)

Industrial and scientific relations

Scientific collaborations

58 ANR 20 european projects
- France: Institut Pasteur, CNRS, INSERM, Hôpital Cochin, CEA, Ecole Polytechnique
- Europe: Portugal, suède, Italie, Angleterre
- International: USA, Liban

Private collaborations

Large group: Danone France, Chr Hansen company (Denmark), SMEs: Bioprox France

Ecosystem

Establishments of affiliation

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Thematics

Current thematics

  • Energy, Ecology, Environment
    • New energy sources and production system
  • Quality of life - Health - Food
    • Animal health and nutrition
    • Food safety and quality
Title

Current content

MICrobiologie de l'ALImentation au Service de la Santé Humaine
Type

Current content

Research unit
Workforce

Current content

Effectif total : 340
Nombre de chercheurs : 130
Nombre de doctorants : 140
Description

Current content

MICALIS develops innovative research in the field of Microbiology of Food for Health. The researchers at this unique institute in France are working on the study of food and intestinal microbial ecosystems and interactions with the host, emergence and control of opportunistic foodborne pathogenic microorganisms as well as microbial systemic and synthetic biology. The institute is home to 5 technological platforms: - Axenic animal facility - Microscopy and imaging of microorganisms, Southwestern Paris proteomic analysis - Microbial-yeast resources - Preindustrial demonstration of intestinal metagenomics. The work and patents on the improvement of the production of edible leaven, the prevention of the microbiological risk in the food chain and the production of tools for the diagnosis of human pathologies and nutritional and probiotic strategies, allows the institue to be an active socio-economic partner (Probiox, Danone).
Contact informations
Contact

Current content

Contact name Email phone number
Philippe-NOIROT philippe.noirot@inrae.fr
URL

Current content

http://www.micalis.fr/

Address

Current content


Domaine de Vilvert
78350 JOUY-EN-JOSAS
Lab of attachment

Current content

Keywords

Current content

Genomics, bioinformatics, microbiology, synthetic biology, agronomy, biotechnology, cell biology, metagenomics
Our search domains
Expertises

Current content

- microbiota
- meat ecosystem
- encephalic and metabolic pathologies
- bioadhesion and materials hygiene
- bacterial communication
- microbial genetics and environment
- firmicutes and environment
- microbial adaptation
- bacterial wall
- bacterial genetics
- biofilm in bacillaceae virulence and fungal infection
- epigenetics
- cellular microbiology
- microbial lipid metabolism
- bacterial communication
- functional integration of cellular processes
- bioinformatics
- bacteriophage genomes
Applications sectors

Current content

Agri-food industry

Agriculture

Health / Wellness

Equipments

Current content

Academics and industry: Mass Spectrometers: - Qexactive - LTQ-Orbitrap - LTQ-XL Microscopy: transmission electron microscopy, scanning microscope, confocal laser scanning, structured illumination microscopy (Apotome), videomicroscopy, Medical Imaging for Animal Development and Reproduction, Cellvizio-Lab endomicroscopy, bioluminescence imaging on small animals, Virtual blades scanner
Our results
Valuation offer

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Offers types

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Examples of work

Current content

- identification and use of a new beneficial commensal bacterium, Faecalibacterium prausnitzii, on the basis of human clinical data: Publication in PNAS at the end of 2008 (450 citations in ISI Wb of Knowledge), Obtaining a project from the Unique Interministerial Fund In the amount of ? 4 million, a first patent filed on peptides and development of the first gnotobiotic model with F. prausnitzii (recently published in BMC Biol.)
- screening of a panel of 150 strains of lactic acid bacteria that led to the identification of a new probiotic strain of Lactobacillus plantarum that has been shown to be effective against the influenza virus. This work was published in AEM and a patent. Our industrial partner conducted a clinical trial of this strain, the results of which will be known in September 2013
- identification of new mechanisms involved in the microbiota / host dialogue. Supported by 3 industrial projects Syndifrais and by funding INRA young team. Using gnotobiotic animals, microbiota and food-borne bacteria have been shown to influence the structure and functions of absorption and protection of the intestine (Faseb J 2013, Isme J, 2014).
- we have developed new concepts of therapeutic innovations based on the use of recombinant bacteria (Gene Therapy, 2008, Science Translational Medicine, 2012)
Publications

Current content

Scientific collaborations

Current content

58 ANR 20 european projects
- France: Institut Pasteur, CNRS, INSERM, Hôpital Cochin, CEA, Ecole Polytechnique
- Europe: Portugal, suède, Italie, Angleterre
- International: USA, Liban
Private collaborations

Current content

Large group: Danone France, Chr Hansen company (Denmark), SMEs: Bioprox France
Ecosystem
Affiliated institutions

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Institutional groups

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Research departments

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PIA links

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Competitivness clusters

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Carnot Institutes

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Doctoral school

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