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Quality of life - Health - Food
Laboratory of Signalling and Cardiovascular Pathophysiology (SPC)
Research unit
The SPC revolves around three teams developing complementary themes on animal and cell models to study the mechanisms involved in cardiac function through membrane receptors, ion channels, cyclic nucleotides, energy metabolism, calcium, and intracellular compartments. The unit aims to elucidate new pathophysiological mechanisms and identify new therapeutic targets in the treatment of heart failure and arrhythmias. It is in charge of innovative projects within the LabEx LERMIT in partnership with other laboratories of the IPSIT.
Innovation themes
17 Avenue des Sciences
Faculté de Pharmacie
91400 ORSAY
Expertises
- heart metabolism
- mitochondria
- electrophysiology
- calcium homeostasis
- homeostasis cAMP, cGMP
Applications sectors
- IT / software
- Biotechnology
Total number of employees
Number of researchers : 23
Number of doctoral students : 10
Equipment(s) open to collaboration
- Langendorff type cardiac dissociation plant in rats, mice - patch-clamp posts
- fluorescence imaging stations, FRET
- confocal microscope
- echocardiography
- cell culture rooms L1 and L2
- flow cytometer
- myographs
- oxygraphy
Keywords
Valuation offer
- Isolation of rat and mouse cardiomyocytes
- Evaluation of mitochondrial function in situ
- Flow cytometry
- Cardiovascular functional exploration
- Cardiac contractility on whole organ and permeabilized fibers
- Metabolic phenotyping
- FRET imaging cAMP, cGMP
- Single channel (RyR) on lipid bilayer
- Patch-clamp technique
Patents:
- 5 patents pending. Example: INSERM Patent (PCT / EP2006 / 001903): Use of an Epac canal antagonist for the Treatment of Cardiac Hypertrophy in Humans
Projects examples
- CSIC (Spain): study of the leptin role in cardiac pathologies
- Stefanik Program (Slovakia): Cardiac and muscular ultrastructure in pathophysiology
- Parrot Program (Estonia): Mitochondrial dynamics in neurons and cardiac and muscle cells
- COFECUB-CAPES program (Brazil) & Maimonides (Israel): research collaboration for the students exchange
Industrial and scientific relations
Scientific collaborations
- France: CRSSA, INSERM, Cochin Institute, UPMC, UVSQ, CNRS, Marie Lannelongue Hospital, CHU Paris Nord Val de Seine, Institute of Myology, Joseph Fourier University, University of Paris VII Diderot, IGF, Lariboisière Hospital
- Europe: Germany, Switzerland, Italy, Estonia, Slovakia, Austria, Norway, Belgium, Poland, Croatia, Sweden, Czech Republic, Spain, England
- International: Brazil, United States, Canada, Cuba, Algeria, Tunisia, Mexico, Israel, Morocco
Private collaborations
- collaboration with several major companies
Establishments of affiliation
