Laboratory of Signalling and Cardiovascular Pathophysiology (SPC)

- cardiovascular physiology and physiopathology
- heart metabolism
- mitochondria
- electrophysiology
- calcium homeostasis
- homeostasis cAMP, cGMP

• IT / software
• Biotechnology

Total number of employees : 44
Number of researchers : 23
Number of doctoral students : 10

Academics and industry:
- Langendorff type cardiac dissociation plant in rats, mice - patch-clamp posts
- fluorescence imaging stations, FRET
- confocal microscope
- echocardiography
- cell culture rooms L1 and L2
- flow cytometer
- myographs
- oxygraphy

Expertises:
- Isolation of rat and mouse cardiomyocytes  
- Evaluation of mitochondrial function in situ
- Flow cytometry
- Cardiovascular functional exploration
- Cardiac contractility on whole organ and permeabilized fibers
- Metabolic phenotyping
- FRET imaging cAMP, cGMP
- Single channel (RyR) on lipid bilayer
- Patch-clamp technique

Patents:
- 5 patents pending. Example: INSERM Patent (PCT / EP2006 / 001903): Use of an Epac canal antagonist for the Treatment of Cardiac Hypertrophy in Humans

- IGR (France): study of radio- and chemo-induced cardiotoxicity in anti-cancer treatments
- CSIC (Spain): study of the leptin role in cardiac pathologies
- Stefanik Program (Slovakia): Cardiac and muscular ultrastructure in pathophysiology
- Parrot Program (Estonia): Mitochondrial dynamics in neurons and cardiac and muscle cells
- COFECUB-CAPES program (Brazil) & Maimonides (Israel): research collaboration for the students exchange

Scientific collaborations

- France: CRSSA, INSERM, Cochin Institute, UPMC, UVSQ, CNRS, Marie Lannelongue Hospital, CHU Paris Nord Val de Seine, Institute of Myology, Joseph Fourier University, University of Paris VII Diderot, IGF, Lariboisière Hospital
- Europe: Germany, Switzerland, Italy, Estonia, Slovakia, Austria, Norway, Belgium, Poland, Croatia, Sweden, Czech Republic, Spain, England
- International: Brazil, United States, Canada, Cuba, Algeria, Tunisia, Mexico, Israel, Morocco

Private collaborations

- collaboration with several major companies

• Network - Aviesan

• SDV (Life sciences)

• LabEx LERMIT