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Laboratory of Signalling and Cardiovascular Pathophysiology (SPC)

Research unit


The SPC revolves around three teams developing complementary themes on animal and cell models to study the mechanisms involved in cardiac function through membrane receptors, ion channels, cyclic nucleotides, energy metabolism, calcium, and intracellular compartments. The unit aims to elucidate new pathophysiological mechanisms and identify new therapeutic targets in the treatment of heart failure and arrhythmias. It is in charge of innovative projects within the LabEx LERMIT in partnership with other laboratories of the IPSIT.


  • Mrs Ana-Maria GOMEZ

Innovation themes

Map and access

17 Avenue des Sciences
Faculté de Pharmacie
91400 ORSAY

Our research areas


- cardiovascular physiology and physiopathology
- heart metabolism
- mitochondria
- electrophysiology
- calcium homeostasis
- homeostasis cAMP, cGMP

Applications sectors

  • IT / software
  • Biotechnology

Total number of employees

Total number of employees : 44
Number of researchers : 23
Number of doctoral students : 10

Equipment(s) open to collaboration

Academics and industry:
- Langendorff type cardiac dissociation plant in rats, mice - patch-clamp posts
- fluorescence imaging stations, FRET
- confocal microscope
- echocardiography
- cell culture rooms L1 and L2
- flow cytometer
- myographs
- oxygraphy


Our results

Valuation offer

- Isolation of rat and mouse cardiomyocytes  
- Evaluation of mitochondrial function in situ
- Flow cytometry
- Cardiovascular functional exploration
- Cardiac contractility on whole organ and permeabilized fibers
- Metabolic phenotyping
- FRET imaging cAMP, cGMP
- Single channel (RyR) on lipid bilayer
- Patch-clamp technique

- 5 patents pending. Example: INSERM Patent (PCT / EP2006 / 001903): Use of an Epac canal antagonist for the Treatment of Cardiac Hypertrophy in Humans

Projects examples

- IGR (France): study of radio- and chemo-induced cardiotoxicity in anti-cancer treatments
- CSIC (Spain): study of the leptin role in cardiac pathologies
- Stefanik Program (Slovakia): Cardiac and muscular ultrastructure in pathophysiology
- Parrot Program (Estonia): Mitochondrial dynamics in neurons and cardiac and muscle cells
- COFECUB-CAPES program (Brazil) & Maimonides (Israel): research collaboration for the students exchange

Industrial and scientific relations

Scientific collaborations

- France: CRSSA, INSERM, Cochin Institute, UPMC, UVSQ, CNRS, Marie Lannelongue Hospital, CHU Paris Nord Val de Seine, Institute of Myology, Joseph Fourier University, University of Paris VII Diderot, IGF, Lariboisière Hospital
- Europe: Germany, Switzerland, Italy, Estonia, Slovakia, Austria, Norway, Belgium, Poland, Croatia, Sweden, Czech Republic, Spain, England
- International: Brazil, United States, Canada, Cuba, Algeria, Tunisia, Mexico, Israel, Morocco

Private collaborations

- collaboration with several major companies


Establishments of affiliation