IPSIT / Plateforme Interactions moléculaires (INTERMOL)

Molecular interactions play a central role in the living world, whether they are interactions between proteins, glycoproteins, lipoproteins or even between DNA or RNA molecules. In the pharmaceutical field, knowledge of the interactions between these macromolecules and molecules of pharmaceutical interest, generally of smaller size, is essential to design new drugs. The objective of the "Molecular Interactions" platform is to propose complementary study techniques adapted to the detailed study of these interactions.

At present, the platform is composed of a surface plasmon resonance (SPR) equipment of type Biacore T100 (GE Healthcare). Complementary techniques such as isothermal calorimetric titration (ITC), differential scanning calorimetry (DSC), a quartz crystal microbalance (QCM) or fluorescence microscopy are also available at the Faculty of Pharmacy of Châtenay-Malabry.

In partnership with the TRANS-PROT Transcriptomics platform of IPSIT, a new activity is being developed: the platform proposes to study the stability of proteins, interaction partners, and to highlight their interactions with ligands.

The SPR apparatus is open to all laboratories of the Faculty of Pharmacy, Paris Saclay University, other academic laboratories and industrial companies.

• Mrs Magali NOIRAY
• Mr Gilles PONCHEL
• Mr Hervé HILLAIREAU