The Pathological Macroassemblies and Prion Diseases (MAP2) team has been working in the field of prion diseases since the late 1990s. One of the major specificities of the team lies in the diversity and multidisciplinarity of the approaches developed, encompassing the physical and structural biochemistry of the prion, the biology and the pathophysiology of this infectious agent. The main research axis of the team is focused on the exploration of the molecular basis of the conformational diversity of the prion in relation to its replicative, adaptive and evolutionary mechanisms, as well as the neurodegenerative phenomena associated with the prion replicative process. The biophysics platform set up by the MAP2 team allows both the expression and purification of proteins as well as the characterisation of protein and nucleoprotein assemblies, biomembranes and bioinspired assemblies.
Domaine de Vilvert
VIM, INRAE, centre de Jouy-en-Josas