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Quality of life - Health - Food
Stress génotoxique et cancer
Research unit
The GSC laboratory studies the genetic and genotoxic events that occur in the development of cancers. The work is shared among 8 teams working in synergy on DNA replication, its repair, recombination phenomena, RNA and miRNA regulation, oxidative stress and radiation response.
Integrated in the Orsay Research Center, the GSC benefits from an integrated imaging platform and the numerous technical platforms of the Institut Curie (SGA, experimental radiotherapy, high-throughput DNA sequencing, etc.).
Innovation themes
Centre Universitaire, Bâtiment 110
91405 ORSAY
Expertises
- DNA biology, damage, repair, replication, recombination
- oxidative stress, replication stress, exogenous stress (radiation)
- RNA biology, miRNAs regulation
- chemotherapy resistance/ radiotherapy
- study in oncology models
- bloom syndrome, leukemias
- tubulin and microtubules regulation in human pathologies
Applications sectors
- Biotechnology
- Health / wellness
- Education / Training
- Chemistry / Plastics (Glue, Plastic, Rubber...)
Total number of employees
Number of researchers : 26
Number of doctoral students : 16
Equipment(s) open to collaboration
- Leica 4 / 5D Routine Inverted Microscope
- Leica 2D Routine Inverted Microscope
- Leica 3D Right Microscope
- Leica 3D Optical Microscope + OptiGrid
- Leica SP5 confocal microscope (FLIM and biphotonic imaging)
- Nikon Inverted Video Microscope, with Ilas2 (Roper) systems and rotating disc
Keywords
Projects examples
- International: international project ENIGMA (Evidence-based Network for the Interpretation of Germline Mutant Alleles)
Industrial and scientific relations
Scientific collaborations
- France : Curie Institute, IGR, Inserm CRLC, Inserm EICB, CNRS IGM, UPMC IMPMC, Pasteur Institute
- Europe : England
- International : Canada, USA
Establishments of affiliation
