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Stress génotoxique et cancer

Research unit


The GSC laboratory studies the genetic and genotoxic events that occur in the development of cancers. The work is shared among 8 teams working in synergy on DNA replication, its repair, recombination phenomena, RNA and miRNA regulation, oxidative stress and radiation response.
Integrated in the Orsay Research Center, the GSC benefits from an integrated imaging platform and the numerous technical platforms of the Institut Curie (SGA, experimental radiotherapy, high-throughput DNA sequencing, etc.).


  • Mr Stephan VAGNER

Innovation themes

Map and access

Centre Universitaire, Bâtiment 110
91405 ORSAY

Our research areas


- cancers physiopathology (solid tumors, circulating cells)
- DNA biology, damage, repair, replication, recombination
- oxidative stress, replication stress, exogenous stress (radiation)
- RNA biology, miRNAs regulation
- chemotherapy resistance/ radiotherapy
- study in oncology models
- bloom syndrome, leukemias
- tubulin and microtubules regulation in human pathologies

Applications sectors

  • Biotechnology
  • Health / wellness
  • Education / Training
  • Chemistry / Plastics (Glue, Plastic, Rubber...)

Total number of employees

Total number of employees : 62
Number of researchers : 26
Number of doctoral students : 16

Equipment(s) open to collaboration

Academics and industry:
- Leica 4 / 5D Routine Inverted Microscope
- Leica 2D Routine Inverted Microscope
- Leica 3D Right Microscope
- Leica 3D Optical Microscope + OptiGrid
- Leica SP5 confocal microscope (FLIM and biphotonic imaging)
- Nikon Inverted Video Microscope, with Ilas2 (Roper) systems and rotating disc


Our results

Projects examples

- France: ANR HetTub project (Molecular mechanisms and functions of tubulin heterogeneity)
- International: international project ENIGMA (Evidence-based Network for the Interpretation of Germline Mutant Alleles)

Industrial and scientific relations

Scientific collaborations

- France : Curie Institute, IGR, Inserm CRLC, Inserm EICB, CNRS IGM, UPMC IMPMC, Pasteur Institute
- Europe : England
- International : Canada, USA


Establishments of affiliation