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Signalisation, radiobiologie et cancer (SCR)

Research unit

Description

The ETIC unit is responsible for major discoveries in the field of developmental biology, particularly in the neural crest and melanocyte lineage, as well as in the pathophysiology of melanoma and retinoblastoma. It works to elucidate the cellular and molecular mechanisms of normal and tumor development of melanocytes with the dual objective of identifying therapeutic targets and leading to new treatments in melanomas associated or not with radiotherapies. In collaboration with clinicians at the Curie Institute, teams can work with samples of patients with melanoma. They also benefit from the numerous technical platforms of the Institut Curie as well as the Protontherapy site on the Orsay campus.

Contacts

  • Mr Jose-Arturo LONDONO-VALLEJO

https://science.curie.fr/recherche/biologie-et-chimie-des-radiations-cellulaires-et-cancer/signalisation-normale-et-pathologique-de-lembryon-aux-therapies-innovantes-des-cancers/

Innovation themes

Map and access

UMR 3347/U1021, Institut Curie - Centre Universitaire, Bâtiment 110
91400 ORSAY

Our research areas

Expertises

- classification and physiopathology of melanoma
- development of neural crests
- microphthalmia, melanoma of the eye and retinoblastomas
- cell lines and in vivo models for the study of melanomas
- damage and DNA repair, repair inhibition
- epithelial-mesenchymal Transition
- MAPK, TGF-beta, PI3K, Wnt / beta-cat signaling in oncogenesis
- miRNA involved in melanoma
- therapeutic innovation
- pre-clinical studies

Applications sectors

  • Biotechnology
  • Health / wellness
  • Education / Training

Total number of employees

Total number of employees : 67
Number of researchers : 34
Number of doctoral students : 14

Keywords

Our results

Projects examples

- France: Phase I clinical trial (DRIIM, NCT 01469455) DT01 in combination with radiotherapy for the treatment of melanoma in transit
- International (Japan, Switzerland): A subpopulation of smooth muscle cells, derived from melanocyte-competent precursors, prevents patent ductus arteriosus, PloS on 06/02/2013

Industrial and scientific relations

Scientific collaborations

- France: AP-HM, Inserm, Curie institut, CNRS, University Paris V Descartes, University Pierre-Marie Curie VI , AP-HP, CEA, University of Strasbourg, ParisTech Mines, EPFL, Univ., Aix-Marseille
- Europe: Italy, Germany, Belgium, Ireland, Sweden, Switzerland
- International: United States, Japan, Canada, Singapore

Private collaborations

- France: Sanofi, Chanel, DNA Therapeutics (Start-up)

Ecosystem

Establishments of affiliation

Groupements institutionnels

  • Network - Aviesan

Département(s) de recherche

  • SDV (Life sciences)

Liens PIA

  • LabEx CellTisPhysBio