• Quality of life - Health - Food

Physiopathogenesis and treatment of liver diseases

Research unit


The goal of the Physiopathogenesis and Treatment of Liver Diseases Unit is to develop translational research in hepatic pathologies on two major themes: hepatic cancers on the one hand and hepatitis (including viral) on the other hand with the will to propose innovative therapies. It is made up of renowned researchers and clinicians as well as ATRs who make the bridge between the laboratory and the patient's bed. The unit is very involved in international clinical trials for the management of hepatic carcinomas and hepatitis. Furthermore, it benefits from the equipment provided by the Lwoff Institute technical platform and the Hepatinov DHU experts network.


  • Mr Jean-Charles DUCLOS-VALLEE

Innovation themes

Map and access

12-14, av. Paul Vaillant Couturier
Centre Hépato-Biliaire, Hôpital Paul Brousse

Our research areas


- liver physiology and physiopathology
- management of liver diseases (including carcinomas)
- transplantation, transplant rejection, immunity
- liver cancer
- acute and chronic hepatitis, steatosis
- cytoskeletal dynamics
- mitochondrial regulation, autophagy
- viruses associated with hepatitis and carcinomas (HBV, HCV ...)

Applications sectors

  • Biotechnology
  • Health / wellness

Total number of employees

Total number of employees : 85
Number of researchers : 41
Number of doctoral students : 10


Our results

Projects examples

- ALFACT Innovation: Phase I clinical trial and randomized European multicenter study for ALF-5755 in acute liver disease
- MODHEP project (FP7): Systems biology of liver cancer, an integrative genomic-epigenomic approach http://www.modhep.eu/
- Inserm U1110: HRas induces HCV penetration in hepatocytes by targeting the tetraspanine receptor (Cell Host and Microbe 2013)

Industrial and scientific relations

Scientific collaborations

- France: Inserm, ENS Cachan, CEA, INRA - Europe: Spain, England
- International: China, Lebanon


Establishments of affiliation