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Quality of life - Health - Food
Physiologie et physiopathologie endocrinienne
Research unit
The HORMENDO unit focuses on endocrine hormone signaling and its pathophysiological aspects in humans. It focuses on several themes: the physiological and physiopathological mechanisms of steroid hormones action and the neuro-endocrine of the hypothalamic-pituitary-gonadal axis.
Composed of biologists and clinicians working in synergy, the laboratory has international recognition in translational research in molecular endocrinology. This close collaboration allows the unit to work with exceptional cohorts of patients with neuroendocrine diseases, development or endocrine tumors.
Innovation themes
63, rue Gabriel Péri
94276 LE KREMLIN-BICÊTRE
Expertises
- signaling of steroid hormone receptors
- functions of brown and white adipocytes
- pituitary and adrenal tumorigenesis
- pathophysiology of the hypothalamic-pituitary-gonadal axis
- physiology and pathophysiology of folliculogenesis
Applications sectors
- IT / software
- Biotechnology
Total number of employees
Number of researchers : 19
Number of doctoral students : 6
Equipment(s) open to collaboration
- Unit equipments: Easydoc (Biorad), StepOne Plus (96 well) and QS6 (384 well) (Applied Biosystems) quantitative PCR device, Luminometer and fluorimeter (Victor Perkin and Tristar, Berthold), TissueLyser (Qiagen), nanodrop 2000 (Thermo Scientific), Pipetting automat (BK4000, Beckman Coulter), scintillation beta counter (Perkin), Odyssey (Licor), L1 and L2 culture rooms (CX3 CO2 and PSM II incubators), freezers -150 °C), FPLC (Biorad), bacteriological incubators (InforsHT Ecotron multiron standard), Bioruptor Pico (Diagenode), Axiovert 35M microscopes (Zeiss), Eclipse E800 (Nikon), AX70, BX61, TL4 (Olympus)
- laboratory of molecular genetics of the CHU: PCR quantitative 7900 device, sequencing miseq (Illumina)
- Biomedical Institute of Bicêtre (I2B, UMS 32): high-speed microscope (Arrayscan, Thermo scientific), LC-MSMS (Xevo TQS Waters), electron and confocal microscope, two conventional laboratory animal supplies
Keywords
Valuation offer
- hormonal signaling
- functional characterization of hormonal receptor mutations
- establishment of immortalized cells and murine models of human pathologies
- 3D modeling
- cellular imaging
- high throughput sequencing and identification of genomic targets (ChIP)
Patent: development and characterization of novel progesterone receptor antagonists.
Database: data from high-throughput sequencing and genomic target identification (ChIP).
Biological material: biological collections (tumor library, DNA library, plasmatheca, urothèque).
Cohorts: patients with rare endocrine diseases (hypogonadotropic hypogonadisms, acromegaly and reproductive diseases, pediatric and neonatology endocrinology, (Cohort PREMALDO, cohorts of newborns and premature infants)
Projects examples
- pituitary and adrenal tumorigenesis
- mutations of steroid receptors, ontogenesis of the mechanisms regulating the hydromineral equilibrium
- development of new antagonists of the mineralocorticoid receptor
Industrial and scientific relations
Scientific collaborations
- France: numerous collaborations with local and national research structures (INSERM, CNRS, INRA, CEA, university) in particular with UMR_S999, UMR_S1180.
Participation in ANR and PHRC projects
- Europe: University of Edinburgh (UK), University of Lausanne, participation in European networks COST
- International: various collaborations including University of Otago (NZ), USA, Canada, Japan-Industries: HRA Pharma, HAC Phama, Bayer Health Care
Private collaborations
- France : HAC Pharma, HRA Pharma
- Europe : Bayer Pharma
Establishments of affiliation
