• Chemistry - Materials
  • Complex systems and software engineering
  • Digital
  • Energy, Ecology, Environment
  • Quality of life - Health - Food
  • Social - Societal - Solidarity Innovation

Department of Analytical and Structural Chemistry and Biology

Research team

Description

The Department of Analytical and Structural Chemistry and Biology at ICSN has several research topics focused on analytical chemistry and structural biology. It relies on exceptional equipment and strong expertise in molecular modeling, structural crystallography, mass spectrometry, nuclear magnetic resonance (NMR), molecular / cellular biology and various purification / analysis methods.The projects carried out are based, for example, on the monitoring the distribution of compounds of interest in various tissues or biological materials, the study of complex mixtures, the structure determination of compounds extracted from plants or synthesis, the understanding of reaction mechanisms, the study of the 3D structure and dynamics of small molecules and biological macromolecules (alone or in interaction with partners or inhibitors) in the context of structural biology and drug design.This department belongs to the Institute of Chemistry of Natural Substances (ICSN) and has a long tradition of academic and industrial collaborations.

Contacts

  • Mrs Carine VAN HEIJENOORT

https://icsn.cnrs.fr/recherche/cbsa

Innovation themes

Lab of attachment

Map and access

1, avenue de la Terrasse
91198 GIF-SUR-YVETTE

Our research areas

Expertises

- structure determination of small molecules and macromolecules
- elemental analyzes in C, H, N, O and S
- mass spectrometry imaging- chromatography mass spectrometry coupling (lipidomic, metabolomic)
- proteomics and characterization of post-translational proteins modifications
- target protein interactions
-inhibitors by molecular modeling, X-ray crystallography, NMR, Thermal Shift Assay (TSA)
- characterization of complex mixtures- quantification of DNA / RNA by quantitative PCR
- TSA determination of protein melting temperature
- advanced NMR spectroscopy (fast methods, dynamic phenomena, pulse sequences)
- molecular modeling (screening in silico, molecular dynamics)
- protein enrichment methods in stable isotopes in eukaryotic cells

Applications sectors

  • Biotechnology
  • Agri-food industry
  • Chemistry / Plastics (Glue, Plastic, Rubber...)
  • Cosmetics

Total number of employees

Total number of employees : 36
Number of researchers : 22
Number of doctoral students : 8

Equipment(s) open to collaboration

Academic and industry:
- mass spectrometers: MALDI TOF-TOF / TOF-SIMS / ESI-Q-TOF / LC-MS-MS / SFC-MS-MS
https://icsn.cnrs.fr/recherche/cbsa/ms/instruments
https://icsn.cnrs.fr/plateformes/lcms
- HPLC chains: chiral column, multiple detection (UV, DEDL, Fluo, Masse), SFC
https://icsn.cnrs.fr/plateformes/lcms
- NMR spectrometer: 10 narrow-bore Bruker devices, from 300 MHz to 950 MHz with probes BBO, BBI, Dual C13, QNP, cryosonde TCI, HR-MAS, CP-MAS, high-pressure
https://icsn.cnrs.fr/recherche/cbsa/biologie-et-chimie-structurales
https://icsn.cnrs.fr/plateformes/rmn
- phenotypic screening plateform and screening at broadband on isolated target
https://icsn.cnrs.fr/plateformes/cibi
- chemical library
https://icsn.cnrs.fr/plateformes/chimiotheque
- extractothèque
https://icsn.cnrs.fr/plateformes/extractotheque
- dynamic light scattering (DLS)
- Thermal Shift Assay (DSF/TSA)
https://icsn.cnrs.fr/plateformes/ctpf
- quantitative PCR (qPCR)
https://icsn.cnrs.fr/plateformes/qpcr
- computing cluster

Keywords

Our results

Valuation offer

- consulting
- equipment provision, service provision, NMR collaboration, mass spectrometry, HPLC, qPCR, TSA, microanalysis, molecular modeling, structural crystallography
- training in our expertise areas: short sessions or laboratory reception of staff over long period, program à la carte or not, reception of doctoral scholarship CIFRE

Projects examples

- development of mass spectrometry imaging techniques for the lipid analysis of tissues related to Duchenne muscular dystrophy, atherosclerosis, or Alzheimer's disease but also the analysis of heritage objects (painting)
- characterization of proteins or small molecules complex mixtures in extracts, cells, or tissues (plants, tumor cells) in natural abundance or enriched in stable isotopes
- study of intrinsically disordered proteins or regions regulating intracellular signaling, viral replication or precursors of antimicrobial lasso peptide
- real-time monitoring of fast chemical reactions for the determination of reaction mechanisms
- design of novel protein inhibitors involved in antibiotic resistance or cancer (apoptosis)
- study of the structure and interactions of proteins in important networks involved in cancer (tumor reversion, ErbB2), viral infections responsible for acute bronchitis in infants (human respiratory syncytial virus) or dengue fever
- development of mass spectrometry and NMR methods to accelerate spectral collection, increase sensitivity, improve structural information content, and molecular modeling to increase the quality of predictions

Industrial and scientific relations

Scientific collaborations

- France: the CBSA department has a long tradition of academic collaborations at the national level with chemistry and biology laboratories of different universities and organizations (CNRS, CEA, INSERM, INRA, Institut Pasteur), LABEX (CHARMMMAT, CEBA, LERMIT) and schools (ISIPCA) and also in hospitals
- Europe: University of Southampton (United Kingdom), Ecole Polytechnique Fédérale de Lausanne (Switzerland), BIOMARGIN Project: Biomarkers of renal graft injuries in kidney allograft recipients
- International: Tübitak (Turkey), University of São Paolo (Brazil), Ritsumeikan University (Japan), University of California Santa Barbara (USA), NIH Bethesda (USA), Arizona State University (USA)

Private collaborations

Many industrial contracts (provision of equipment, collaboration, service provision) are regularly implemented with large companies, SMEs or startups in the pharmaceutical, biotechnology, food and scientific instrumentation sectors.

Ecosystem

Establishments of affiliation

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Thematics

Current thematics

  • Chemistry - Materials
    • Analytical chemistry
  • Complex systems and software engineering
    • Modelling and simulation
    • Software design, big data, cloud, high performance computing
  • Digital
    • Digital modelling, data visualisation, Human - Machine Interaction
    • Free software, web
  • Energy, Ecology, Environment
  • Quality of life - Health - Food
    • Food safety and quality
    • Therapeutic technologies (drugs, genetics, biomarkers, biomolecules, etc.)
  • Social - Societal - Solidarity Innovation
    • Environment, energy and food
Title

Current content

Department of Analytical and Structural Chemistry and Biology
Type

Current content

Research team
Workforce

Current content

Effectif total : 36
Nombre de chercheurs : 22
Nombre de doctorants : 8
Description

Current content

The Department of Analytical and Structural Chemistry and Biology at ICSN has several research topics focused on analytical chemistry and structural biology. It relies on exceptional equipment and strong expertise in molecular modeling, structural crystallography, mass spectrometry, nuclear magnetic resonance (NMR), molecular / cellular biology and various purification / analysis methods.The projects carried out are based, for example, on the monitoring the distribution of compounds of interest in various tissues or biological materials, the study of complex mixtures, the structure determination of compounds extracted from plants or synthesis, the understanding of reaction mechanisms, the study of the 3D structure and dynamics of small molecules and biological macromolecules (alone or in interaction with partners or inhibitors) in the context of structural biology and drug design.This department belongs to the Institute of Chemistry of Natural Substances (ICSN) and has a long tradition of academic and industrial collaborations.
Contact informations
Contact

Current content

Contact name Email phone number
Carine-VAN HEIJENOORT carine.van-heijenoort@icsn.cnrs-gif.fr
URL

Current content

https://icsn.cnrs.fr/recherche/cbsa

Address

Current content

1, avenue de la Terrasse

91198 GIF-SUR-YVETTE
Lab of attachment

Current content

Institut de Chimie des Substances Naturelles (ICSN)
Keywords

Current content

mass spectrometry, NMR, molecular modeling, structural crystallography, qPCR, TSA, CTPF, microanalysis, molecular and cellular biology, structural biology, biological imaging, post-translational modifications, proteomics, lipidomics, metabolomics, analytical chemistry, structure, conformational dynamics, reaction mechanisms, molecular interactions, drug design, neurodegenerative diseases, cancer, antibiotic resistance, viral infections
Our search domains
Expertises

Current content

- structure determination of small molecules and macromolecules
- elemental analyzes in C, H, N, O and S
- mass spectrometry imaging- chromatography mass spectrometry coupling (lipidomic, metabolomic)
- proteomics and characterization of post-translational proteins modifications
- target protein interactions
-inhibitors by molecular modeling, X-ray crystallography, NMR, Thermal Shift Assay (TSA)
- characterization of complex mixtures- quantification of DNA / RNA by quantitative PCR
- TSA determination of protein melting temperature
- advanced NMR spectroscopy (fast methods, dynamic phenomena, pulse sequences)
- molecular modeling (screening in silico, molecular dynamics)
- protein enrichment methods in stable isotopes in eukaryotic cells
Applications sectors

Current content

Agri-food industry

Biotechnology

Chemistry / Plastics (Glue, Plastic, Rubber...)

Cosmetics

Equipments

Current content

Academic and industry: - mass spectrometers: MALDI TOF-TOF / TOF-SIMS / ESI-Q-TOF / LC-MS-MS / SFC-MS-MS https://icsn.cnrs.fr/recherche/cbsa/ms/instruments https://icsn.cnrs.fr/plateformes/lcms - HPLC chains: chiral column, multiple detection (UV, DEDL, Fluo, Masse), SFC https://icsn.cnrs.fr/plateformes/lcms - NMR spectrometer: 10 narrow-bore Bruker devices, from 300 MHz to 950 MHz with probes BBO, BBI, Dual C13, QNP, cryosonde TCI, HR-MAS, CP-MAS, high-pressure https://icsn.cnrs.fr/recherche/cbsa/biologie-et-chimie-structurales https://icsn.cnrs.fr/plateformes/rmn - phenotypic screening plateform and screening at broadband on isolated target https://icsn.cnrs.fr/plateformes/cibi - chemical library https://icsn.cnrs.fr/plateformes/chimiotheque - extractothèque https://icsn.cnrs.fr/plateformes/extractotheque - dynamic light scattering (DLS) - Thermal Shift Assay (DSF/TSA) https://icsn.cnrs.fr/plateformes/ctpf - quantitative PCR (qPCR) https://icsn.cnrs.fr/plateformes/qpcr - computing cluster
Our results
Valuation offer

Current content

- consulting - equipment provision, service provision, NMR collaboration, mass spectrometry, HPLC, qPCR, TSA, microanalysis, molecular modeling, structural crystallography - training in our expertise areas: short sessions or laboratory reception of staff over long period, program à la carte or not, reception of doctoral scholarship CIFRE
Offers types

Current content

Examples of work

Current content

- development of mass spectrometry imaging techniques for the lipid analysis of tissues related to Duchenne muscular dystrophy, atherosclerosis, or Alzheimer's disease but also the analysis of heritage objects (painting)
- characterization of proteins or small molecules complex mixtures in extracts, cells, or tissues (plants, tumor cells) in natural abundance or enriched in stable isotopes
- study of intrinsically disordered proteins or regions regulating intracellular signaling, viral replication or precursors of antimicrobial lasso peptide
- real-time monitoring of fast chemical reactions for the determination of reaction mechanisms
- design of novel protein inhibitors involved in antibiotic resistance or cancer (apoptosis)
- study of the structure and interactions of proteins in important networks involved in cancer (tumor reversion, ErbB2), viral infections responsible for acute bronchitis in infants (human respiratory syncytial virus) or dengue fever
- development of mass spectrometry and NMR methods to accelerate spectral collection, increase sensitivity, improve structural information content, and molecular modeling to increase the quality of predictions
Publications

Current content

Scientific collaborations

Current content

- France: the CBSA department has a long tradition of academic collaborations at the national level with chemistry and biology laboratories of different universities and organizations (CNRS, CEA, INSERM, INRA, Institut Pasteur), LABEX (CHARMMMAT, CEBA, LERMIT) and schools (ISIPCA) and also in hospitals
- Europe: University of Southampton (United Kingdom), Ecole Polytechnique Fédérale de Lausanne (Switzerland), BIOMARGIN Project: Biomarkers of renal graft injuries in kidney allograft recipients
- International: Tübitak (Turkey), University of São Paolo (Brazil), Ritsumeikan University (Japan), University of California Santa Barbara (USA), NIH Bethesda (USA), Arizona State University (USA)
Private collaborations

Current content

Many industrial contracts (provision of equipment, collaboration, service provision) are regularly implemented with large companies, SMEs or startups in the pharmaceutical, biotechnology, food and scientific instrumentation sectors.
Ecosystem
Affiliated institutions

Current content

Institutional groups

Current content

Research departments

Current content

PIA links

Current content

Competitivness clusters

Current content

Carnot Institutes

Current content

Doctoral school

Current content

Personal informations
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