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Quality of life - Health - Food
Signalling, Nuclei and Innovations in Oncology
Research unit
The laboratory Signaling, nuclei and innovations in oncology works on understanding the main nuclear functions of cells responsible for cancers. The various parameters studied are: membrane trafficking, macromolecular complexes, proteomics and epigenetics, intracellular organization, resistance to apoptosis in B cell lymphoma, the tumoral microenvironment, exosomes / micro RNA and finally collective invasion and epithelial morphogenesis. In particular, the laboratory uses molecular and cellular imaging to obtain a three-dimensional view of the mechanisms involved in oncogenesis. This work is at the origin of the several patents realized thanks to numerous partnerships with industrialists.
Innovation themes
114, rue Edouard Vaillant
94800 VILLEJUIF
Expertises
- intra-nuclear organization and pathological models
- oncogenesis and resistance to apoptosis in B-cell lymphoma
- maintenance of genomes, molecular microscopies and bionanosciences
- tumoral microenvironment, exosomes and micro-RNA in solid tumors
Applications sectors
- Health / wellness
- Biotechnology
Total number of employees
Number of researchers : 12
Number of doctoral students : 14
Keywords
- Immune restoration
- galectin-9
- nasopharyngeal carcinoma
- circulating tumor
- miRNAs
- metabolism
- TORC1 pathway
- autophagy
- tumor suppressor
- cell biology
- DNA repair and recombination
- atomic force microscopy
- proteomics
- epigenetics
- chromatin
- histones
- proteins interaction
- lymphomas
- Epstein-Barr virus
- apoptosis
- Bcl-2 family
- immunotherapy
Establishments of affiliation
