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Signalling, Nuclei and Innovations in Oncology

Research unit


The laboratory Signaling, nuclei and innovations in oncology works on understanding the main nuclear functions of cells responsible for cancers. The various parameters studied are: membrane trafficking, macromolecular complexes, proteomics and epigenetics, intracellular organization, resistance to apoptosis in B cell lymphoma, the tumoral microenvironment, exosomes / micro RNA and finally collective invasion and epithelial morphogenesis. In particular, the laboratory uses molecular and cellular imaging to obtain a three-dimensional view of the mechanisms involved in oncogenesis. This work is at the origin of the several patents realized thanks to numerous partnerships with industrialists.


  • Mrs Joëlle WIELS

Innovation themes

Map and access

114, rue Edouard Vaillant

Our research areas


- membrane transport, macromolecular complexes and cancer
- intra-nuclear organization and pathological models
- oncogenesis and resistance to apoptosis in B-cell lymphoma
- maintenance of genomes, molecular microscopies and bionanosciences
- tumoral microenvironment, exosomes and micro-RNA in solid tumors

Applications sectors

  • Health / wellness
  • Biotechnology

Total number of employees

Total number of employees : 40
Number of researchers : 12
Number of doctoral students : 14


Our results


Establishments of affiliation